ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection
Fig 3
RNA-seq analysis of viral and human transcripts during HSV infection.
(A) Reads mapped to the HSV genome as a percentage of total mapped reads (HSV+human) per sample. Data shown are the average of 2 independent experiments. Differential gene expression of human and HSV genes in (B) uninfected ATRX-KO cells/uninfected Control cells, (C) 7134 infected ATRX-KO cells/7134 infected Control cells at 8 hpi, (D) 7134 infected Control cells 8 hpi/uninfected Control cells, (E) 7134 infected ATRX-KO cells at 8 hpi/uninfected ATRX-KO cells as determined by comparing fold change vs adjusted p-value (padj). Data shown is the average of 2 independent experiments.