Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity
Table 5
List of large structural variations in the isolates of Patient 1.
Using isolate P1Bm2009 as a reference, we mapped the long Nanopore reads of the subsequent isolates from Patient 1 to reveal large structural variations that escape SNP analysis. All structural variations are found in C1 and are fixed after their appearance in agreement with the SNP analysis (Fig 8). Isolates P1Bm2011a and P1Bm2012b, which originated from the same sputum sample as P1Bm2011b and P1Bm2012a, respectively, appear to come from separate lineages.