ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis
Fig 1
ASC-dependent inflammasomes contribute to the pathogenesis of HSV-1 encephalitis.
(A) Survival curve of WT (n = 17), NLRP3-/- (n = 14), AIM2-/- (n = 11), and ASC-/- (n = 15) mice infected intracranially with 3x104 PFU HSV-1 KOS. Results are combined from seven inoculations. (B) Whole brain titers of infected WT, NLRP3-/-, and ASC-/- mice at days 1, 3, and 4 post-infection (n = 7–12 per group, 8 inoculations). (C) Whole brain IL-1β and (D) IL-18 from WT, NLRP3-/-, and ASC-/- mice either before infection or at days 1 and 3 post-infection (n = 4–5 per group). Values are expressed as means ± SEM (**P < 0.01, ***P < 0.001, ****P < 0.0001).