Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice
Fig 2
hFcRnTg32-IFNAR-/- adult mice are permissive to E11 infection.
C57/BL6 (WT, gray), hFcRnTg32 (light blue), IFNAR-/- (dark blue), and hFcRnTg32-IFNAR-/- (red) animals were IP inoculated with 104 PFU of E11 and sacrificed 72 hours post inoculation. (A) Viral titers in the blood (log10PFU/mL) of adult animals (WT– 11, hFcRnTg32–10, IFNAR-/-– 16, hFcRnTg32-IFNAR-/-– 23 animals). Viral titers in the liver (B), pancreas (C), stool (D), small intestine (E), and brain (F) (log10PFU/mg) from adult mice are shown as mean ± standard deviation bars and individual animals (points). Data are shown with significance determined with a Kruskal-Wallis test with a Dunn’s test for multiple comparisons (*p<0.05, **p<0.005, ***p<0.0005, ****p<0.0001).