T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics
Fig 4
Amino acid variation at RT135 in Japanese and Canadian individuals with subtype B HIV-1 over 2 decades.
A. HIV-1 RT135 amino acid frequencies in 1,478 Japanese non-hemophiliac individuals with chronic HIV-1 subtype B before 1997, and between 1998–2003, 2004–2009, and 2010–2015. The cohort is analyzed overall, and stratified by HLA allele carriage as follows: HLA-B*51:01+B*52:01-C*12:02- (n = 212); HLA-B*51:01-B*52:01+C*12:02+ (n = 302); and HLA-B*51:01-B*52:01-C*12:02- (n = 964). Statistical analysis was conducted using the Cochran-Mantel-Haenszel test (See also S2 Table). B. RT135 amino acid frequencies in 6,258 Canadian individuals with chronic HIV-1 subtype B recruited from 2000 to 2015. "X" indicates a mixture of two or more amino acids at that residue (as bulk HIV-1 sequencing was performed).