Transferrin receptor 1 levels at the cell surface influence the susceptibility of newborn piglets to PEDV infection
Fig 9
The schematic of intracellular iron levels influences the susceptibility of newborn piglets to TfR1 mediated PEDV infection.
(A) Iron deficiency improved PEDV invading. High expression of TfR1 on the surface of intestinal epithelial cells in iron deficient newborn piglets, promotes PEDV infection. TfR1 may be a receptor for PEDV infection; the PEDV S1 protein interacts with the extracellular portion of TfR1, PEDV attachment causes TfR1 clustering, recruits Src kinase, actives TfR1 tyrosine 20 phosphorylation, and induces the formation of clathrin coated endocytic vesicles, which results in TfR1-bound PEDV internalization. (B) Iron overload inhibited PEDV infection. Under the conditions of iron overload, the expression of membrane TfR1 is decreased, thus curbing the PEDV invasion.