Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
Fig 5
HIV-Low individuals show higher methylation levels in interferon stimulated genes and lower methylation levels in genes related to T follicular helper (Tfh).
All differentially methylated CpG positions in the dataset (p<0.05) are shown in the context of two different pathways. A) Pathway representing genes associated with antiviral and interferon response focused on Role of RIG-I like Receptors in Antiviral Innate Immunity, Antiviral activation of IRF by cytosolic pattern recognition receptors and Interferon Signaling canonical pathways from IPA. B) Scheme showing T Helper Cell Differentiation canonical pathway from IPA combined with reported genes associated with Tfh phenotype. Coloring is based on methylation fold-change HIV-High/HIV-Low. Red refers to lower methylation in HIV-Low, and green higher methylation in HIV-Low. Also, pink and blue in (A) indicate the ISGs that are induced via type I or type II interferon, respectively. Molecules selected in the multivariate are highlighted with a blue border. Solid lines indicate direct interactions and dashed ones, indirect interactions.