Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation
Fig 6
Surface representation of ChiA-CTD showing the spatial distribution of Zn2+ ions during MD simulations. The sdf is represented with isosurfaces connecting points with sdf = 20 (green mesh), 25 (yellow mesh) and 30 (red surface) x average sdf. Zn2+ high-density sites (red surface) around the chitinase and peptidase active sites are numbered 1 to 8. Blow out boxes show representative structures from the MD simulations to illustrate Zn2+ binding in the eight regions, with Zn2+ ions shown as spheres, their coordinating residues as sticks and ChiA-CTD as cartoon.