PGRP-LD mediates A. stephensi vector competency by regulating homeostasis of microbiota-induced peritrophic matrix synthesis
Fig 7
Model of influence of PGRP-LD on A. stephensi competence.
(A) PGRP-LD protects gut microbiota by negatively regulating immune responses. The gut microbes promote integrity of PM, which enhances vector resistance to parasite infection. (B) Knock down of pgrp-ld leads to the upregulation of immune effectors, which kills a significant number of gut microbes. Dysbiosis of the gut microbiota results in the presentation of a structurally compromised PM, which facilitates P. berghei infection.