Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes
Fig 10
DENV infection perturbs cellular energy production from lipids.
The schematic shows the carnitine shuttle translocating fatty acyl-CoA from the cytosol into the mitochondrial matrix for fatty acid degradation (β-oxidation) and two hypotheses (I and II) to explain the accumulation of medium-chain length acyl-carnitines and the diversion of FA-CoAs during DENV infection. Hypothesis I represents a pathway where an accumulation of acyl-carnitines is observed because β-oxidation in the mitochondria is inhibited or blocked by infection. Hypothesis II represents a pathway that leads to mitochondrial overload during infection due to increased energetic demands. Abbreviations: CPTI, carnitine palmitoyl transferase I; CPTII, carnitine palmitoyl transferase II; and FA-CoA, fatty acyl-CoA. Red arrows represent the hypothesized flow of intermediates occurring during infection.