MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection
Fig 1
Qa-1 expression is upregulated during aerosol Mtb infection.
(A) Expression of Qa-1 on leukocytes from mediastinal lymph node (MLN) of low-dose Mtb-infected C57BL/6 mice at 2, 4, and 6 weeks post-infection, as compared to uninfected B6 mice or isotype control. (B) MFI of Qa-1 expression on B cells (B220+ CD11c-), dendritic cells (DC) (CD11c+), T cells (TCRβ+), and macrophages (Mϕ) (CD11b+ F4/80+) from MLN of high-dose-infected B6 mice at 4 weeks post-infection, as compared to uninfected mice. Representative of 3 independent experiments, n ≥ 2 per group. * p < 0.05, ** p < 0.01, *** p < 0.001.