Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients
Fig 8
Biofilm formation of isolates with 5 bp deletion, compensatory mutations, which were complemented with the wild-type ica genes.
Biofilm formation of the strains with compensatory mutations in icaA, icaD or icaC was abrogated. A) Isolates of patient 7. B) Isolates of patient 8. Transformation with a vector expressing the appropriate wild-type ica gene conferred biofilm formation.