Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
Fig 9
Modeling of rate of cleavage of WT, V362I, V370A and ΔV370 Gag VLPs in the presence of MIs.
Simulation of log10 reduction in the observed rate of cleavage (kclv,ob) as a function of MI concentration. Upper panel: model 1, affinity and cleavage data, MI-unbound VLP (k1 term only); Lower panel: model 2a, affinity, MI-unbound VLP (k1 term) plus (MI-bound VLP term k2 (derived from incorporating antiviral MPI values from the multiple cycle assay). A) and C) BMS-955176, B and D) BVM.