Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi
Fig 3
IL-17A alone is not responsible for the Th17-mediated enhanced protective effects.
(A-B) T. cruzi-specific Th17 cells were co-transferred with CD8+ T cells into RAG KO mice (5/group) prior to T. cruzi challenge. Neutralizing anti-IL-17A or control IgG1 antibodies were injected intraperitoneally every 48 hours. IL-17A neutralization did not reduce protection as measured by both parasitemia (A) and survival (B). *p<0.001 by two-tailed Student t test, **p<0.01 by log-rank test compared with negative controls. (C-D) Polyclonal CD8+ T cells were transferred intravenously (i.v.) into RAG KO mice prior to T. cruzi infection. Either control AdV or IL-17 AdV was injected 1 day prior to infection and 7 days post-infection at 5x109 PFU i.v. Protection was measured by parasitemia 18 days post-infection (C) and survival (D).