Role of Ultraviolet Radiation in Papillomavirus-Induced Disease
Fig 6
Long-lived immune suppression in UVB-irradiated mice correlates with papilloma incidence.
Mice were either infected with MmuPV1 or vehicle followed by UVB irradiation (300mJ/cm2) in the right ear. Mice were sensitized with DNCB 10 days post UVB exposure and were challenged DNCB in the left ear 3 months following infection. Ear swelling was measured by means of a Vernier calipers. Ear thickness is reported as the average of the difference between ear thickness 0 hrs post challenge and 72 hrs post challenge. Ear thickness for each mouse is shown as a dot plot. The black lines represent the mean reading for each group. Wilcoxon rank-sum test was used to analyze difference between several groups. There was significant difference between UVB-irradiated (UV) and control (no UV) groups (*p = 0.021, two-sided). There was significant difference between the UVB irradiated animals infected with MmuPV1 that developed warts and those that did not develop warts (**p = 0.016, two-sided). There was no significant difference between control (no UV) and UVB-irradiated mice infected with MmuPV1 that did not develop warts (MmuPV1+ UV without warts).