Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury
Fig 1
IL-4/STAT6 signaling pathway is essential for larval growth.
Area of larvae recovered from (A)–(C), C57BL/6, STAT6-/-, IL-4-/- and IL-13-/- mice injected 25,000 NBL IV, 13 days post injection. Total body larval burdens in muscles of (D) WT and STAT6-/- and (E) WT and IL-4-/-, 24 days post injection. (F) IL-10 detected in CLN cultures from WT and STAT6-/- mice, 13 days post injection. (G) Number of CD4+IL-10+ cells per diaphragm of WT and IL-4-/- mice, 13 days post injection. Each data set was collected from two experiments with similar results. Values represent mean ± SD; n = 4 mice. Significant differences were determined by Student’s t test. ***p < 0.0001.