Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System
Fig 2
A delay in viral spread is observed in brain of rOC/SG758R -infected mice compared to rOC/ATCC after intranasal inoculation in 10 day-old BALB/c mice.
Histological examination of virus spread within the brain of 10-day old BALB/c mice infected with 103.25 TCID50/10μL of rOC/ATCC or rOC/SG758R, or PBS by the IN route. (A) Detection of viral antigens in the olfactory bulb of infected mice at 5 and 7 dpi. (B) Detection of viral antigens in the hippocampus of infected mice at 7 and 9 dpi. Magnification 40x.