An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation
Fig 1
Mice were infected with 105 PFU of H1N1, pH1N1, or H5N1 virus, three mice per infection group were euthanized at 14 time points after infection (0, 3, 6, 9, 12, 18, 24, 30, 36, 48, and 60 h and 3, 5, and 7 days), and virus titers in lung tissues were determined by plaque assays in MDCK cells. Error bars illustrate the standard deviation from the mean. The gray boxes at each time point identify significant pairwise differences between the means of the viruses indicated at the right of the figure panel (significance was determined by ANOVA followed by Tukey’s Honestly Significantly Different test, P < 0.05). *, three H5N1-infected mice intended for collection on day 7 succumbed to their infections prior to sample collection.