The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection
Fig 7
Rag1-/- mice receiving ADAP-/- T cells reduces protection in response to H5N1 virus infection.
Four days after Rag1-/- mice were transferred with 4×106 CD4+ and 2.5×106 CD8+ T cells purified from wild type or ADAP-/- splenocytes, the recipient mice were then infected with the H5N1 virus GX/12 (106 EID50) for the following analysis at day10 post infection (n = 5): bodyweight loss (A), HE staining of lungs (B), surface CD103 expression on the lung infiltrating CD8+ T cells (C), and the amount of viral NP (nucleoprotein) in lungs by IHC staining (D). Data are representative of two independent experiments.