RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets
Fig 3
Absence of eosinophils does not affect T cell responses.
Total number of (A) CD4 and (B) CD8 T cells in the lung of vaccinated WT and eosinophil-deficient mice was enumerated on days 4 and 6 following RSV infection. Number of IL-10, IFN-γ, IL-5, and IL-13 producing CD4 T cells in the lungs of immunized WT and dblGATA-1 mice was determined on days (C) 4 and (D) 6 post-infection. Data are represented as mean ± SEM of two independent experiments (n = 7 mice total for FI-mock, n = 8 mice for FI-RSV). Groups were compared using one-way ANOVA, ** p<0.01, *** p<0.001.