A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection
Figure 2
GzmBW cleaves Bid more efficiently and procaspases less efficiently than GzmBP.
In vitro translated 35S-labeled mouse procaspase 3, mouse procaspase 7, or mouse Bid were incubated with the indicated amounts of granzymes at 37°C for 30 min. Products were separated by 15% SDS-PAGE and visualized by fluorography.