A Locus Encompassing the Epstein-Barr Virus bglf4 Kinase Regulates Expression of Genes Encoding Viral Structural Proteins
Figure 11
A model depicting regulation of late gene expression by the G-locus.
A schematic diagram illustrating the organization of the bglf4 (G4), bglf3.5 (G3.5) and bglf3 (G3) open reading frames in the EBV genome. Four canonical TATA box elements located in this locus are present upstream of the bglf3, bglf3.5, bglf5 and bblf1 genes [33], [47], [73]. The asterisks denote three mapped transcription start sites of transcripts encoding BGLF4. A poly(A) signal is located at the 3′ end of the bblf1 gene. Solid lines represent the predicted transcripts synthesized from this locus. Our findings postulate that both BGLF4 and BGLF3 function to activate expression of late genes.