CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
Figure 4
PbT-I cells induce ECM in mice lacking endogenous CD8+ T cells.
B6 mice were either left undepleted (closed triangles) or were depleted of endogenous CD8+ T cells (-CD8) seven days before the adoptive transfer of 2×106 naïve PbT-I (filled square) or gBT-I cells (filled circle) or no cells (open triangles). The next day, mice were infected i.v. with 106 blood-stage PbA and monitored for the development of cerebral malaria. Data are pooled from three experiments. The difference in survival between the following groups was statistically significant (p<0.0001) as determined by the Log-Rank test: i. B6, -CD8, + PbT-I and B6, -CD8; ii. B6, -CD8, + PbT-I and B6, -CD8, + gBT-I.