Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents
Figure 6
Analysis of DAA-resistant mutations emerged during treatment protocols by direct sequencing.
In the long-term HCV infection assay shown in Figure 5A, HCV RNA in the supernatants from different treatments was purified on day 23. Direct sequencing was performed to identify predominant viral mutations in HCV NS3 protease region as described in Materials and Methods. Data are displayed as NS3 amino acid sequence in treated cells.