Rhinovirus Attenuates Non-typeable Hemophilus influenzae-stimulated IL-8 Responses via TLR2-dependent Degradation of IRAK-1
Figure 2
RV infection prolongs lung inflammation caused by NTHi and suppresses initial chemokine response.
Mice were infected with sham or RV followed by NTHi as described in Figure 1. (A and B) Hematoxylin and eosin stained lung sections from Sham/NTHi-infected mice at 1 and 3 days post NTHi infection respectively. (C to E) Hematoxylin and eosin stained lung sections from RV1B/NTHi-infected mice at 1, 3 and 7 days post NTHi infection respectively. Inserts in the top left corners of A, C and D are magnified view of area marked in respective panels showing neutrophils. (Fand G) Chemokine levels in lung homogenate supernatants were determined by ELISA. Images in A to E are representative of 3 to 4 animals per group. Data in F and G represent mean±SD (n = 4–9, * p≤0.05, two-way ANOVA, different from sham; # p≤0.05, two-way f ANOVA, different from sham/NTHi infected animals).