Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7
Figure 4
CD4-use efficiency correlates with CD4 binding site neutralization sensitivity.
The y-axis shows sensitivity to CD4bs mAbs b12 (A) and VRC01 (B) as measured by the maximal percent inhibition (MPI) using 10 µg/ml of each mAb. Envs were divided according to their CD4-use efficiency; those that used CD4 efficiently were more sensitive to CD4bs antibodies than Envs that used CD4 inefficiently. The bar represents the median MPI value and p-values are from two-tailed Mann-Whitney tests.