Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice
Figure 8
Epitope-specific CD8+ T cell precursor frequency analysis in adult and neonatal mice.
(A) Precursor frequencies of epitope-specific CD8+ T cells in naïve adult and neonatal mice as determined by the double tetramer enrichment method. (B) KdM282-90/DbM187-195 precursor frequency ratios in naïve adults and neonates. (C) Epitope-specific memory CD8+ T cell precursor frequencies in adult mice infected one month previously with RSV. (D) Memory CD8+ T cell precursor ratios. Data are representative of several independent experiments with 5-12 mice/group. Error bars represent the SEM.