Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt
Figure 8
Mortality and weight loss of mice infected with rEG/D1 viruses.
Six-week-old BALB/c mice (7–8 mice per group) were inoculated intranasally with the indicated doses of rEG/D1, rEG/D1Q192H, rEG/D1129Δ,I151T, rEG/D1-EG/12 HA and rEG/D1-EG/12 HAH192Q. (A) Body weight of infected mice was monitored up to 14 d post-infection. Mean percent body weight change (±SD) for each group of mice is shown. (B) Survival of mice inoculated with rEG/D1 viruses. Mortality was calculated including mice that were sacrificed because they had lost more than 30% of their body weight. (C) Virus titers in lungs of mice infected with 3×104 or 3×105 FFU rEG/D1 at the indicated times post-infection. Circles and diamonds indicate values in individual mice.