Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens
Figure 7
Conformation of CD46 at the cell surface.
Two views of the entire CD46 protein, indicating possible orientations on the cell surface. The ribbon drawings show the CD46-4D structure, with domains SCR1-SCR4 colored as in Figure 3. Native glycosylation was modeled as described in the Methods section. The STP region (grey box) comprises about 30 amino acids that are not included in our structure. These residues carry O-linked glycosylation and likely serve as a spacer between the base of SCR4 and the membrane. Arrows indicate likely sites of interaction with C3b (panel A) and viruses (panel B).