Correction: Transcriptional profiling of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection
Fig 3
Comparison of transcriptional profiles of Tlr2-/- and wild-type neurons during T. gondii infection.
Upregulated (A, C, E) and downregulated (B, D, F) genes were identified as genes with 2-fold change and < 0.05 FDR in DESeq analysis comparing infected and uninfected cells. (A, B) Venn diagrams comparing DEGs with increased and decreased abundance between Tlr2-/- and wild-type neurons. (C, D) To explore the function of DEGs analyzed in the Venn diagram, GO term enrichment analysis was performed. Asterisks represent significant differences with p < 0.05 in Fisher’s exact test. (E, F) Expression of top 20 genes highly upregulated or downregulated in a TLR2-dependent manner. TLR2-dependent DEGs were ranked according to fold-changes between infected and uninfected wild-type. WT, wild-type; KO, Tlr2-/-.