Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice
Fig 7
Embryo area versus embryonic age for embryos with maternally inherited Naa10 knockout allele, where the allele originated from the maternal grandmother (DDD) or the maternal grandfather (AAA).
(A) Weight gain of Naa10-/+ (DDD dams) and Naa10+/- (AAA dams) at various lengths of gestation were compared. We observed no statistically significant difference between both simple linear regression lines that represent the weight gains of dams from both mating series at each length of pregnancy (P>0.05). (B) Left: Embryo area versus embryonic age for DDD vs. AAA Naa10+/Y males. Right: Embryo area versus embryonic age for DDD vs. AAA Naa10-/Y males. (C) Left: Embryo area versus embryonic age for DDD vs. AAA Naa10+/+ females. Right: Embryo area versus embryonic age for DDD Naa10-/+ vs. AAA Naa10+/- females. There are no statistically significant differences between the embryo areas for each genotype from each mouse line (P>0.05). Graphs B-C were produced using nonlinear exponential regression modeling.