Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F
Fig 6
Natural mutations of QTY-code and rQTY-code.
Native structures are represented in green, while the predicted effects of QTY and reverse QTY mutations are illustrated with colored residues: blue = benign, orange = possibly damaging with low confidence, red = damaging with high confidence. a NET, b DAT, c SERT, d VMAT1, e VMAT2, f VAChT, and g VPAT. For clarity, N- and C termini and large loops are deleted.