IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells
Fig 4
IL-17A-depleted A549 cells prevent tumor metastasis-induced bone destruction in vivo.
(A) X-ray images of the tibias of mice at 4 weeks after A549 cell-injection. (B) Quantitative analysis of osteolytic bone destruction. (C) Hematoxylin and eosin (HE) and (D) TRAP staining of one representative tibia from each group. (E) Quantitative analysis of osteoclast numbers in bone metastases of A549 cells. Data are expressed as number of osteoclasts/mm at the tumor-bone interface and the mean ± SD. Arrows indicate osteoclasts; # tumor mass. **p < 0.01. Scale bar, 50 μm.