AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells
Fig 5
Docked complex of AM-18002 with STAT3.
(A) The surface representation of STAT3 displaying deep penetration of AM-18002 into the SH2 domain of STAT3 (PDB:1GB1) (B) Docked conformation of AM-18002 in the SH2 domain of STAT3 (PDB:1BG1). The key amino acid residues are represented as stick structures (color code: navy blue). Hydrogen bonds are shown as yellow lines. (C) Schematic overview of apoptosis induced by AM-18002 via ROS-mediated induction in mouse breast cancer FM3A cells and the signaling pathways that mediate the inhibitory effect of AM-18002 on cancer cell migration and invasion. The image was created using BioRender (www.biorender.com).