Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer’s disease patients
Fig 2
Analysis of alpha- and beta-diversities in human brain tissues.
(A) OTUs of the HT, F, and HC, and those of N and AD are presented as box and whisker plots. (B) The Shannon indexes of the HT, F, and HC, and those of N and AD are presented as box and whisker plots (median: HT = 2.12, F = 1.34, HC = 2.64, N = 2.14, and AD = 2.03). (C) The multidimensional scaling (MDS) plot has been visualized using the Bray–Curtis and the significance of dissimilarities was examined by the permutational multivariate analysis of variance (HT vs F vs HC: R2 = 0.19, P = 0.001, N vs AD: R2 = 0.03, P = 0.647). (D) The Bray–Curtis distances of the N–N and AD–AD samples (Within), and those of N–AD samples (Between) were evaluated. (E) The Bray–Curtis distances of the (1)–(2) samples from the same donor (Within) and those of the samples from different donors (Between) were evaluated. The significance among the HT, F, and HC and between N and AD was examined by the Kruskal–Wallis test and Mann–Whitney U test, respectively.