Upper glycolytic components contribute differently in controlling retinal vascular endothelial cellular behavior: Implications for endothelial-related retinal diseases
Fig 1
Illustration depicting the glycolysis process in HRECs, distinguishing between upper and lower glycolysis.
Upper glycolysis involves the utilization of 2 ATP and begins with the transportation of glucose into HRECs through glucose transporters (Glut). The inhibitors targeting upper glycolytic components, indicated in blue, are WZB117, Lonidamine, PFK158, and TDZD. Abbreviations: GA3P (glyceraldehyde-3-phosphate), TPI (triose phosphate isomerase), DHAP (dihydroacetone phosphate), GAPDH (glyceraldehyde-3-phosphate dehydrogenase), 1,3-Bis-PG (1,3-bisphosphoglycerate), PGK (phosphoglycerate kinase), 3-PG (3-phosphoglycerate), PGM (phosphoglycerate mutase), 2-PG (2-phosphoglycerate), PEP (phosphoenolpyruvate), PK (pyruvate kinase), L-LD (L-lactic dehydrogenase).