Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM
Fig 5
Compounds 13 and 37 react covalently with SYK-tSH2.
(A) Mass spectrometry analysis of SYK incubated with compounds 37 and 13 at 100 μM for 1 h at room temperature. (B) Hypothesized mechanism of inhibition of 37 and 13 with SYK-tSH2.