Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling
Fig 6
Pairwise contrasts identify the differentially expressed genes between foreskin, cervix, and tonsil-derived 3D epithelia.
(A) Euler diagram with area-proportional ellipse for each pairwise contrast, including up (red) and down (blue) genes. (B-D) Volcano plots of the DESeq2 pairwise contrast results. The top five up- and down-regulated genes are labeled. (E-G) Ridge plots of the aggregated core enriched gene distribution (log2 fold change) from pairwise gene set enrichment analysis (GSEA): non-redundant functional modules from network analysis of the statistically significant Gene Ontology Biological Process (GO:BP) terms are shown (S3–S5 Figs). The number of core enriched (leading edge) genes are shown beside each distribution. Red = enriched. Blue = depleted.