Ion exchange chromatography as a simple and scalable method to isolate biologically active small extracellular vesicles from conditioned media
Fig 3
Transmission electron microscopy (TEM) characterization.
Fractions 2 to 5, in which particles were detected, were subjected to TEM analysis. Vesicular structures were only found in fractions 3 and 4. Inset: close-up view of a vesicle.