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Ion exchange chromatography as a simple and scalable method to isolate biologically active small extracellular vesicles from conditioned media

Fig 2

Size and distribution analysis of the different fractions.

(A) Representative size distribution profile of fractions 2 to 5 measured by tunable resistive pulse sensing (tRPS). (B) Mean particle concentration for each fraction (mean±SD from five independent samples).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0291589.g002