Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma
Fig 5
RV1001 arm differential gene expression between poor and good responders at baseline.
(A) Differentially expressed genes in poor responders as compared to good responders (n = 2 poor and 4 good responders; log2fold change < or > 1.5 and p<0.01.) A heatmap was constructed using the same significance criteria. (B) Normalized gene counts for PIK3CD were higher in good responders, and approached significance (p = 0.0528.) Normalized gene counts for AKT3 and PTEN were significantly upregulated in good responders (p = 0.0201 and 0.0461, respectively.) Counts for NRAS were significantly upregulated in poor responders (p = 0.01.) Comparisons were made using unpaired t tests.