Endotoxin induced acute kidney injury modulates expression of AQP1, P53 and P21 in rat kidney, heart, lung and small intestine
Fig 1
The microarray analysis results of septic AKI.
(A) Gene expression profiling of kidney at 6h after CLP-induced AKI compared with the control group. Volcano plot of log2 fold changes versus -log10 FDR showed transcriptional differences between the CLP-induced AKI group and the control group. Vertical dashed lines denote the cutoff of 2-fold change, and the horizontal dashed line represents the 0.05 FDR cutoff. AQP, P53and P21 was increased after 6 h renal CLP-induced AKI in Rat (fold change>2, FDR<0.05). (B) The expression of AQP, P53 and P21 in kidney at 6h after CLP induced AKI. Data are expressed as the mean ± SE. *p < 0.05, **p < 0.01.