https://orcid.org/0000-0001-7960-7056
Figures
Abstract
Background
People affected by Neglected Tropical Diseases (NTDs), specifically leprosy, Buruli ulcer (BU), yaws, and lymphatic filariasis, experience significant delays in accessing health services, often leading to catastrophic physical, psychosocial, and economic consequences. Global health actors have recognized that Sustainable Development Goal 3:3 is only achievable through an integrated inter and intra-sectoral response. This study evaluated existing case detection and referral approaches in Liberia, utilizing the findings to develop and test an Optimal Model for integrated community-based case detection, referral, and confirmation. We evaluate the efficacy of implementing the Optimal Model in improving the early diagnosis of NTDs, thus minimizing access delays and reducing disease burden.
Methods
We used a participatory action research approach to develop, implement, and evaluate an Optimal Model for the case detection, referral, and management of case management NTDs in Liberia. We utilized qualitative and quantitative methods throughout the cycle and implemented the model for 12 months.
Results
During the implementation of our optimal model, the annual number of cases detected increased compared to the previous year. Cases were detected at an earlier stage of disease progression, however; gendered dynamics in communities shape the case identification process for some individuals. Qualitative data showed increased knowledge of the transmission, signs, symptoms, and management options among community health workers (CHW).
Conclusion
The results provide evidence of the benefits of an integrated approach and the programmatic challenges to improve access to health services for persons affected by NTDs. The effectiveness of an integrated approach depends on a high level of collaboration, joint planning, and implementation embedded within existing health systems infrastructure.
Citation: Godwin-Akpan TG, Chowdhury S, Rogers EJ, Kollie KK, Zaizay FZ, Wickenden A, et al. (2023) The development, implementation, and evaluation of an optimal model for the case detection, referral, and case management of Neglected Tropical Diseases. PLoS ONE 18(5): e0283856. https://doi.org/10.1371/journal.pone.0283856
Editor: Dziedzom Komi de Souza, University of Ghana Noguchi Memorial Institute for Medical Research, GHANA
Received: May 26, 2022; Accepted: March 19, 2023; Published: May 10, 2023
Copyright: © 2023 Godwin-Akpan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting Information files.
Funding: This study was funded by COR-NTD with the support of USAID, BMGF, and UKAID. The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Introduction
Globally, people affected by Neglected Tropical Diseases (NTDs), specifically those affecting the skin, including leprosy, Buruli ulcer (BU), yaws, and lymphatic filariasis, experience significant delays in receiving diagnosis and treatment; this is due to multiple factors, including stigma, a lack of knowledge, accessibility, and gender [1]. However, compounding these challenges is the lack of available appropriate disease management and disability inclusion (DMDI) services of reasonable quality within the community and available through the health system [1, 2]. Stigma and discrimination are very high for people with skin NTDs due partly to the visible physical impairments they cause. Thus, remaining hidden in communities is a typical response to stigma [3, 4]. Stigma and lack of awareness of NTDs further contribute to the delays in health-seeking pathways of people affected by NTDs [2, 5–7] This matter, as the time between symptoms, diagnosis, and treatment, determines the treatment regimen and illness outcome [8]. Early diagnosis and management reduce the risk of significant physical, economic, and psychosocial impacts of NTDs [9]. Thus, addressing the barriers to early case detection is essential to attaining universal health coverage and reducing the disease burden caused by NTDs; this includes a shift from a passive approach to case detection to an active model. The World Health Organization (WHO) has emphasized active case finding as part of the five essential intervention packages to prevent, control, and eliminate NTDs [10, 11]. Integrating active case finding into national NTD programs will promote active surveillance instead of passive data collection to ensure no one is left behind.
NTDs affect more than a billion people worldwide, impacting low-income populations in Africa, Asia, and the Americas [8]. NTDs are described as an equity tracer for the Sustainable Development Goals (SDGs) with specific targets. SDG sub-goal 3:3 states, "to end the epidemics of AIDS, tuberculosis, malaria, and neglected tropical diseases and combat hepatitis, water-borne diseases, and other communicable diseases by 2030" [12]. However, NTDs are a diverse and complex group of 20 tropical diseases that require multiple integrated inter and intra-sectoral responses [13]. NTDs can be divided into preventive chemotherapy and transmission control (PCT) and conditions requiring case management (CM). PCT NTDs are managed at the community level by mass drug administration (MDA), usually administered through vertical health campaigns. CM-NTDs require early diagnosis and management individually, typically provided as part of routine health service delivery [14].
Within this article, integration of NTDs refers to the joint planning, implementation, and evaluation of activities across programs to achieve common goals [15]. Specifically, we consider the integration of case detection interventions for CM-NTDs. Following the launch of the first WHO Roadmap for NTDs [8], emphasis and prioritization have been placed on providing preventative Mass Drug Administration (MDA) for PCT NTDs. There is far less emphasis and attention on disease management, disability, and inclusion (DMDI) services for CM-NTDs (excluding leprosy). Consequently, across many settings, since the early 2010s, MDA interventions for PCT NTDs have been administered simultaneously with evidence of success. However, integrated intervention delivery for CM-NTDs hind globally, as they require new operating models and considerable resource inputs (financial and human) [9, 16, 17].
Consequently, with restricted funding to specific CM NTDs (e.g., Buruli ulcer or leprosy), CM-NTD interventions have been ad-hoc, vertical in approach, and frequently cannot reach affected persons [10]. The global commitment to “leave no one behind” cannot be achieved without support to NTD programs to identify, diagnose, and manage CM NTDs [18]. Furthermore, diagnosis, treatment, and referral delays can lead to the ongoing transmission of CM NTDs of epidemic concern. The persistent disability and morbidity challenges will continue to increase economic hardship for underprivileged families and countries.
Liberia was one of the first countries to adopt an integrated approach to managing CM-NTDs to improve access and universal health coverage for people with NTDs. This approach responded to two national policies: “Essential Package of Health Services” and “Investment Plan for building a resilient health system," which were introduced to support the establishment of a more resilient health system in Liberia following the Ebola Virus Disease (EVD) outbreak [19, 20]. In line with these policies, the NTDs and the National Tuberculosis and Leprosy Control programs, along with several national and international partners, developed a "National Strategic Plan for the Integration of Case Management of NTDs (CM-NTDs) in Liberia (2016–2020)" [21]. The plan extended the National NTDs Masterplan, which follows the WHO NTDs Master Plan template for planning PCT and CM-NTDs interventions. The strategic plan for integrated case management aligns with the four strategic priorities of the WHO NTDs Master Plan. These priorities are 1) government ownership, advocacy, coordination, and partnerships; 2) resource mobilization and planning for results; 3) access to interventions and treatment improved and system capacity building; and 4) monitoring, surveillance, and operational research [21]. The plan includes strategies to integrate case detection, referral, confirmation, and management control for BU, leprosy, clinical manifestations of lymphatic filariasis (hydrocele and lymphedema), and yaws to support the control and elimination of these NTDs by 2020 [21, 22]. The fifteen counties in Liberia are all co-endemic for the targeted diseases requiring case management [21]. Due to funding restraints in 2017, the NTD program launched the integrated plan for case management in five counties: Bong, Bomi, Lofa, Maryland, and Nimba, alongside the integration of national-level activities, including budgeting, performance monitoring, data management, and strengthening the drug supply chain. Through the implementation of the integrated CM-NTDs plan, the NTDs program: developed integrated training manuals for community health workers and health workers; integrated the NTDs supply chain into the national Central Medicine Store; integrated data collection and reporting tools within the national DHIS2 platform; established surveillance, supervision and referral, and diagnostic pathway; and decentralized NTD services by strengthening the capacity of primary healthcare facilities to diagnose and manage uncomplicated NTD cases, while more complex cases are referred to tertiary hospitals for in-patientcare. Decentralization involved capacity strengthening for key community and primary healthcare system members, including supporting community health assistants (CHAs) and community health volunteers (CHVs) to conduct case identification, two-way referrals to health facilities, and follow-up in the community. However, decentralization was complicated and diverse. As a result, the NTD program currently has multiple community-based case detection models in operation (see Fig 1) across the CM-NTD pilot counties. The effectiveness of these differing models in improving patient access to care and early diagnosis has not been documented, thus making it challenging for the NTD program to know how best to target its approach and resources.
Using a participatory action research approach, this study aimed: to evaluate existing approaches to community-based case detection in Liberia (formative phase); to utilize initial evaluation findings to develop an Optimal Model for integrated community-based case detection, referral, and confirmation of CM-NTDs endemic to Liberia (planning phase); to implement the model for 12 months (act phase); and to evaluate the efficacy of the Optimal Model in improving the early diagnosis of CM-NTDs (evaluation phase) (Fig 2). This paper presents findings across each of our study phases to provide lessons for other country settings hoping to embark on integrated approaches for managing CM-NTDs.
Adapted from Lewin, 1946 [23].
Materials and methods
A mixed-method evaluation of the optimal model was conducted. Qualitative methods included key informant interviews, focus group discussions, participant observation, and reflexive sessions. Quantitative data focused on the analysis of routine health systems data.
Study setting
Bong County was purposively selected as the study setting for this research based on the following criteria: Bong County is one of the five counties of the integrated CM-NTDs pilot; co-endemic for all priority diseases; has mixed success in terms of case reporting across its nine health districts (i.e., some have identified more cases than others); and all three models of case detection (Fig 1) have been implemented in this setting—furthermore, Bong shares border with two integrated CM-NTD implementation counties (Nimba and Lofa). Patients may travel between these counties for treatment [24]. The study was conducted in Bong County, Liberia (Fig 3).
Data collection
Study participants were purposively selected based on their role in delivering the optimal model to affected populations and for maximum variation in gender and age. Participants included staff from all health system levels with experience in integrated case detection, referral, and confirmation of NTDs or benefited from NTD services. Table 1 presents the qualitative data collection methods for the evaluation and participants.
Key informant interviews.
Four health facilities in Bong were purposively selected based on geographical variation. A CHSS trained to supervise CHWs in the community in each facility was interviewed as a key informant, using an interview guide. We were particularly interested in their experiences and perspectives of training and supervision, specifically, how the optimal model has impacted case identification, referral, and confirmation at different health system levels.
Focus group discussions.
Five FGDs were conducted with community health workers and peer advocates from across Bong County based on their roles and training. We were interested in their training experience and how cases were identified, referred to, and confirmed using the optimal model at different health system levels. Separate group discussions were held with CHWs and patient advocates. Each focus group discussion had between 5–8 participants.
Participant observation.
Participant observation was conducted at the training of CHWs, supervisors, and peer advocates. A structured observation grid was used to document reflections and observations of interactions, participation, and training content.
Reflexive sessions.
Reflexive sessions involving a participatory group discussion were conducted with the core research team and the County Health Team to reflect on the optimal model’s design, delivery, and evaluation. The core research team remotely participated in a reflexive session over Skype. In contrast, a reflexive session with the county health team was conducted at the health facility, including the NTD focal person and the Community Health focal person in Bong County. The reflexive session included key themes on collaboration, participation, power, evidence use, and reflections on the challenges, strengths, and sustainability of the Optimal Model.
Routine data analysis.
Quantitative data on the utilization of NTDs services were collected using pre-existing and routine NTDs program data reporting tools during the Optimal Model pilot test period (January-December 2020). Existing health systems data was disaggregated by gender and other socio-demographic factors and utilized to collate information about the impact of the optimal model. Descriptive comparisons between the optimal model intervention period (2020) and the preceding year (2019) against key SMART performance-based evaluation indicators are made. These indicators include the number of confirmed cases for NTD morbidity (number of confirmed hydrocele cases, number of confirmed lymphedema cases, percentage of BU cases identified with categories 1 and 2 lesions, percentage of newly identified Leprosy patients presenting with grades two disabilities), and number of confirmed CM-NTD cases per disease.
Data analysis
The qualitative analysis included a transcription of all digitally recorded interviews in English. All data were anonymized and stored securely in a password-protected database. Debriefing sessions with data collectors focused on key findings, identifying saturation themes, and refining inquiry lines. Data were analyzed thematically using a framework approach: the research team read and re-read the transcribed data; developed a coding framework; coded transcripts using NVivo software; discussed emerging themes and refining codes; charted and summarized the data alongside each theme as presented here. The research team analyzed the quantitative data by compiling a list of NTD patients diagnosed over the twelve months recorded in the health facility registers in an excel spreadsheet. SPSS version 24 was used to analyze the individual line list of patients. Quantitative and qualitative data were synthesized together to present a critical reflection of the optimal model presented in the discussion.
Ethics statement
This study was approved by the University of Liberia-Pacific Institute for Research & Evaluation (UL-PIRE) Institutional Review Board (Protocol number: NTDSC 167D) (S1 File).
Inclusivity in global research
Additional information regarding the ethical, cultural, and scientific considerations specific to inclusivity in global research is included in the Supporting Information (S5 File)
Consent and data collection procedure
Informed consent was obtained from each participant in the assessment before FGDs, KIIs, and reflexive sessions. The participants had an opportunity to ask questions about the study and the implications of their participation. Participants’ confidentiality and the right to withdraw from the research at any time during the interview were assured. Upon completing the consent process, each participant received a copy of their signed consent form (S3 File). Anonymizing names and other identifiers-maintained confidentiality.
Results
Development of the optimal model: Inclusion and collaboration
The Optimal Model was developed in partnership with the National Ministry of Health NTD team, the Bong County Health Team, people affected by NTDs, and community health workers with support from national NTD program partners (American Leprosy Missions, Liverpool School of Tropical Medicine, the University of Liberia Pacific Institute for Research and Evaluation) through COR-NTD funding. There was a collaboration between the national program, lower levels of the health system, and persons affected by NTDs during the entire development process. The model was developed in two phases over nine months: phase one, the formative phase, and phase two, the planning phase. During phase one, we conducted a participatory qualitative evaluation of the program’s three models of case detection to identify strengths and weaknesses. We used the results to design an Optimal Model for case detection. This phase drew on qualitative participatory methods, including key informant interviews and focus group discussions with health workers and affected persons on understanding their experiences of existing case detection approaches. During phase two, the planning phase, a two-day workshop was held in Monrovia, Liberia, with stakeholders including persons affected by NTDs, community health workers (CHWs), Bong County Health team, NTD program, and other health stakeholders from the central, county, and district levels to collaboratively develop the optimal model based on the findings from phase one.
The findings included vital themes such as inconsistencies and delays in remuneration, geographical barriers, opportunity costs through the out-of-pocket expenditure of CHWs on transport and calls, and insufficient training and supervision of DMDI services. Challenges regarding gender, disability, and other axes of social disadvantage patients face were also explored to understand how they affect case detection; poverty, social isolation, stigma, and gendered access were highlighted as critical issues. The optimal model included comprehensive training on integrated approaches to identify, refer, diagnose, and manage NTDs at the community level. The training included a referral process, a supervision structure, and incentive packages. The Optimal Model developed is summarized in Fig 4 and detailed in S2 File.
Partnership and collaboration promoted ownership of developing, implementing, and evaluating the optimal model, as stakeholders were involved in all stages. The research and implementation team agreed that collaboration with the County teams, community health workers, and persons affected by NTDs strengthened the design of the optimal model to ensure the language was context-specific and easily understandable at the community level.
’We could bring everyone on board, and everyone gave their collective views on how the intervention phase should be implemented, which gave birth to the development of training materials, development of IEC materials, how to motivate the community and health workers…search for cases.’ (National Program Staff, Reflexive Session)
Optimal model implementation and evaluation
Across all diseases, the annual number of cases diagnosed based on clinical manifestation has increased compared to the previous year (Fig 5). This was particularly noticeable for hydrocele and suspected Buruli ulcer cases, with more than twice the number of cases reported in 2020 compared to 2019 (Fig 6). Cases reported in 2020 are from across all health facilities within Bong County. This is the first year that geographic coverage appears to have reached all health facilities since the original rollout of integrated case detection in 2016/17. Cases were detected at an earlier stage of disease progression. A significant proportion of Buruli ulcer cases was identified with grade I and grade II lesions in 2020 compared to 2019 (Fig 7). Grade 1 lesions would indicate greater capacity and earlier diagnosis in Buruli ulcers. The proportion previously was almost entirely grade II lesions. However, results related to Buruli ulcer should be interpreted with caution due to the limitations in PCR confirmation due to the COVID-19 pandemic and reduced supplies to Liberia.
As discussed in the following sections, multiple systems factors shape the successes and limitations of the optimal model rollout.
Training.
Key strengths of the training included pictorial guides and accessible language, which aided case detection at the community level. Including stigma, education helped CHWs improve their understanding of disease and dispel misconceptions and stigma associated with NTDs. The training also increased knowledge of NTD transmission, signs and symptoms, and management options. The additional training has expanded the program’s reach as health facilities that were previously dormant diagnosed NTDs cases in 2020.
"Yes, from the training, I began to realize that if you have a patient with NTDs, people will begin to stigmatize them; oh, this person got elephantiasis I don’t want to get some. But from the training, my thoughts began to tell me that that person is important no matter of their conditions, so I should learn to live with the person just as how I have to live as human beings" (CHW, FGD, Bong)
’During the development of the revised training modules, it was really nice to have the community of workers make inputs…the language really changed… the community health workers gave a lot of, consideration of all of the diseases in that ’you have to say it in this way, and that really made the revised modules really rich’ (Researcher, Reflexive Session)
The length of training was a key challenge. One day for training was too short, and many CHWs requested longer training sessions or refresher training. Within this pilot, the duration of the COR-NTD training deviated from the original optimal model, which was initially planned to last for two days due to budget constraints. As a result, participants reported feeling rushed and needed more time on the referral forms to practice filling them out correctly.
"The training is for…it’s not supposed to be for twenty-four hours. It is supposed to be for forty-eight hours or seventy-two hours because the notes’ training is so bulky. You can’t use one day to put everything in your brain. You have to take some time to study. Even though they had pretest and posttest. It was okay but it has to take some days to get your brain reminding you of it.” (CSS, KII)
Trust and rapport with communities: The essential role of peer advocates.
Peer advocates are affected by NTDs who have received DMDI services and played a unique role in case-finding activities. Many peer advocates expressed how sharing their experiences has increased trust and encouraged more people to attend the health facility. Peer advocates reported relating well to others affected to address stigma and encourage them to seek treatment.
’My experience is I talk with the person, and I tell him I too have suffered from these kinds of diseases and the Phebe hospital took care of it easily, and he should not be scared…and I too have gone under such an operation, and nothing happened….The good thing I experienced about the training was to talk with those that got the sickness like me, and they got treated and got well like me because I have been in the hospital myself before.’ (Peer Advocates, FGD, Bong)
Gender balance.
Gendered dynamics shaped the case identification process in communities. Men and women felt more comfortable discussing their conditions and being screened by CHWs of the same gender. However, the training sensitized case detectors to consider gender preferences by involving relatives or friends during case detection; many CHWs described that this resulted in affected persons being more likely to cooperate.
’Though the person will find it very difficult to express their condition to you as an opposite gender because traditionally they do not feel secure.
’In identifying cases with women, it’s kind of a little quite different. If she’s married and perhaps she has a problem, if you must be successful in handling that problem, you must firstly engage the husband making sure to let him know what the problem the woman has so he can know what is your role too in the community. So, in my experience on the field, before engaging somebody wife, if she has a problem, I must also let the husband know that I came on the field and this is my job. This is what your wife has and this is what I want to do. He must approve before I can go on with my function.’ (CHWs, FGD, Bong)
Impact of gender on equitable access–a higher proportion of male cases than females was identified across diseases (Fig 8). Five hundred ninety-five males and 109 females participated in the case detection and referral training from the nine health districts in Bong County (Table 2). The CHW training included both males and females between the ages of 25–60 from catchment communities of all the health facilities in Bong County. However, significantly more men than women were in this training, as reflected in the cases detected (Fig 8). A more significant proportion of cases identified as males are shared across all disease conditions across 2019 and 2020, excluding leprosy, where case detection appears equal (Fig 8).
Supervision.
The supervision cascade was effective, as CHWs and CHAs reported feeling supported and encouraged due to the feedback received from supervisors. Some forms needed to be filled out correctly in the first supervision round, but this improved with the second round. According to many CHSS, supervisions were conducted daily in communities where community awareness meetings were held. Coordination amongst the different levels of health cadres in the supervision cascade was a key implementation strength. The previous models did not include this coordinated approach through supervision forms at all levels and a detailed supervision plan.
‘Those who can come visit us we can really enjoy them because some of the thing them there I can’t understand it. So when he comes he can teach me and it can go well with me. For example, I just use to put the date I will not put nothing on it. But my supervisor when she comes she can say no that’s not how you can do it. Do it so. When even you do not find the case, you are supposed to do it so. So it can really encourage me. It building me up to do the work now.’ (CHW, FGD, Bong)
However, logistical challenges such as limitations in transportation, gasoline, and communication cards were mentioned by supervisors as limitations to optimal supervision. Financial constraints in paying for medicines and lack of medication in facilities were crucial challenges. However, this was highlighted by NTD Program staff as being a national issue and not reflective of the optimal model.
‘Our CHSS does not have support like gasoline for his bike and he most often used his own money to purchase gasoline to go on the field to check on us. I think the government needs to find ways to assist him because that’s the only way he too will be able to supervise us.’ (CHW, FGD, Bong)
Referral.
Improvements in referral and reporting as a result of the optimal model were demonstrated through the referral structure. Tools such as referral forms, counter referral forms, and the NTDs ledger improved reporting. The referral process entailed CHWs and peer advocates filling in referral forms in the community and referring the patient to the health facility for confirmation and treatment. When confirmed positive, the patients were put on treatment, with a counter referral form filled by the health facility and sent back to the community as feedback to the CHW who referred the case.
‘But for now, things being better for the past year. Because cases that I have being getting in recent time, as soon I call the county focal person if that case specimen supposed to be collected I get in touch. He will try to connect and try to collect the specimen. As soon that case is confirmed, the drugs will immediately come. As we even speak I get patient in the facility the facility that are on their treatment and they are improving.’ (CHSS, KII, Bong)
However, some CHSS and CHWs described challenges in patient referral, including limitations of forms, financial constraints, and lack of drugs at the health facilities.
The Optimal Model also shows increased health facilities throughout the county that reported cases (Fig 9). However, many patients reported movement limitations at diagnosis due to ulceration. By 2020, more health facilities reported CM NTDs cases referred by CHVs who have been trained and supported through the Optimal Model package than in 2019. Although the number of cases reported in 2019 and 2020 per health facility was deficient, several health facilities reported CM-NTD cases for the first time in 2020 due to the Optimal Model (Fig 9).
Remuneration.
The performance-based incentive package was motivating, as mentioned by many CHWs, although some CHWs experienced delays in receiving the USD 5 incentive packages. Certificates based on the number of cases referred were also considered a source of encouragement. Other sources of motivation include pride in their roles, success stories of patients receiving treatment, and recognition in the community.
’Anytime we find case for me I brought cases here I got bag. I got five dollars. So those are motivating us in order for us to move further. I was motivated really. Because if that after the training, my first case that I found I received bag, five dollars with flashlight.’ (CHW, FGD, Bong)
’What we think could work better is that because most of the time, this five-dollar issue can’t really become a problem in the facility. When the CHV report the cases, the focal person will call you and say the case is confirmed; you will give your feedback to the CHV in the community. They expect their five-dollar at that time but at time it will take long time before the five dollar. All those can make them feel reluctant with the work’ (CHSS, KII, Bong)
Discussion
One of the main objectives of the Optimal Model was to support the earlier identification of NTDs requiring case management to reduce morbidity and disability. For Buruli ulcer, this was successful, with a significant proportion of cases being identified with grade I and grade II lesions in 2020 compared to 2019. This result emphasizes that cases are detected at an earlier stage of disease progression. The training improved case finding across all diseases as the annual number of cases diagnosed had increased in 2020 compared to 2019 in Bong County. We believe the success of the Optimal model implementation was due to the collaborative and inclusive planning and development process that included affected persons, partners, and health workers at all levels of the health system. This inclusivity promotes local ownership and sustainability. Within this discussion, we consider ongoing implementation challenges in the context of the broader literature and make recommendations for continuous service delivery based on our evaluation findings.
This study, to our knowledge, is the first to focus on identifying an optimal model for integrated case detection, referral, and confirmation of NTDs in Liberia. Several studies have been conducted on the integrated case management of NTDs strategy in Liberia, focusing on patient perception, the outcome of care, and case detection [22, 25, 26]. There have been findings on the effectiveness of active case search in increasing the number of cases compared to reliance on passive surveillance at the health facility for specific diseases [27, 28]. However, the findings from this study support improved access to care for affected persons through early case detection.
Integrating different disease conditions within a single training reduced barriers to care for persons affected by NTDs. The collaboration between different cadres of health workers to develop a comprehensive training manual supported enhanced, and early case detection for NTDs affected persons with complex health-seeking journeys. Our study found that integrating these disease conditions into one manual increased CHWs’ knowledge to conduct community awareness to reduce the stigmatization of persons affected by NTDs. The observations in this study are similar to Mitja et al., who found that "the success of an integrated approach will rely on well-trained health workers and village volunteers being able to correctly identify multiple skin conditions" within one interaction [11]. The CHWs benefited from the collaboration across diseases and amongst the different levels of the health system. The knowledge gained and confidence in their ability to provide valuable information on NTDs to community members and identify suspect cases was due to the participation of various stakeholders in developing the training tools and designing the optimal model.
Alongside integrated training, ensuring the right people receive this training and are well-motivated is essential. For example, our study found that Buruli ulcer and hydrocele cases in 2020 were twice reported in 2019. CHWs said this was significantly due to the integrated training and the frequent supervision and incentives, which motivated them to continue active case searches and community awareness. The on-spot mentoring and follow-up during supervision by CHSS provided an opportunity for CHWs to gain more knowledge and confidence to identify cases. This result supports the findings of studies conducted in the Republic of Benin, Cameroon, and Nigeria, which also found increased cases reported with early signs of the disease through referral by trained community health workers [29–32]. In addition, our study prioritized the inclusion of peer advocates as case detectors to build trust with community members and motivate affected persons to visit the health facility for proper diagnosis. Youtsu also found that integrated surveillance requires the training of local health workers (16). Peer advocates’ personal experience with the disease conditions and their understanding of the local community helps reduce stigma and encourage positive healthcare-seeking behaviors. Program decision-makers must carefully select who delivers the activities to impact program outcomes.
Gendered access to patients to identify and refer was a key challenge that qualitative and quantitative data emphasized. The gender disparity in the number of cases diagnosed was linked to the sex of those who received the training. CHWs reported seeking permission from spouses or family members to screen suspected cases of the opposite sex due to cultural norms and fear of stigmatization. This finding is consistent with findings from India that women delayed hospital visits awaiting permission from their husbands or guardians [33]. To address gender inequities in CM-NTD interventions, programs must invest in frontline health workers to improve communication techniques to reduce shame and stigma as barriers to healthcare seeking [34]. Despite the commitment to gender equity within the research, it was impossible to achieve gender parity in training as the community health workforce in Liberia is predominantly male. National programs must proactively advocate for gender balance in recruiting CHWs to ensure that those conducting activities represent the gender makeup of such a community. Additionally, integrating gender in all stages of planning, tool development, testing, implementation, and evaluation will improve the equity and impact of case findings.
Limitations
The delivery of this study was limited by the impact of COVID-19 due to partial lockdowns and social distancing restrictions. Liberia confirmed its first COVID-19 case on March 16, 2020. On April 8, 2020, the President declared a 21-day renewable national state of emergency for residents of all fifteen counties until further notice. This meant no inter-county travels between the capital and other counties and a 3 p.m. to 6 a.m. curfew rather than a total lockdown. During this time, residents were permitted to leave their homes only to procure food or health items, an activity limited to one person per household for one hour within their local area. This state of emergency was extended for two weeks until July 21, 2020. National curfews and movement restrictions meant that case detection activities were suspended, resulting in the low number of cases reported in the quantitative results. The fluctuation in the number of cases detected between February to September 2020 corresponds with the increase in COVID-19 cases in Bong County. Case detection began in February 2020, with high numbers reported after completing the integrated training in January; however, significantly fewer cases were reported with the first lockdown between March and April. In contrast, NTD cases reported between August to September 2020 also decreased when no new COVID-19 were reported in Bong County. This is due to the increased workload for CHWs as other health programs resumed activities after the decrease in COVID-19 cases and the end of lockdown measures.
Many CHWs mentioned how COVID-19 impacted their work in case identification and referrals. People feared attending health facilities for fear of contracting COVID-19. This reduced regular community visits, referrals, and limited health talks. To mitigate the impact of COVID-19 on case detection activities, infection prevention and control measures were implemented. Hand sanitizers and face masks were provided to CHWs to reduce their fear of interacting with community members during case detection.
Furthermore, many CHWs were recruited and trained to conduct COVID-19 surveillance, which was done simultaneously with NTD’s case detection and awareness activities. COVID-19 also affected the work of peer advocates. While peer advocates’ significant role in case-finding was recognized, the duration of their case-finding activities was far less than that of CHWs. As a result, the impact of their work cannot be quantitatively measured for case-finding activities.
Additionally, funding constraints, based on the overall program budget and necessary adaptations for COVID-19 mitigation measures, reduced the number of days for training and supervision. Such limitation did not allow CHWs adequate time to practice using the data collection and reporting tools during the training. This may have contributed to the number of early diagnoses as CHWs may have needed to be more confident in identifying suspected cases at earlier stages of disease progression. Funding limitations and challenges in the quality of routine data collection systems within Liberia meant that including a control county within this study was impossible, thus limiting our understanding of effectiveness. Future studies evaluating the Optimal Model should consider including control activities.
Conclusion
Recommendations for health system strengthening
Implementing the optimal model came with challenges, which are to be anticipated when integrating interventions into emerging health systems. Despite the global impetus towards integration, restrictions on donor funding limited the scope of some activities, e.g., length of training and supervision; greater flexibility concerning the scope and integration within the training of multi-diseases would enable more effective case finding for NTDs. Similarly, a significant area for improvement was the logistical support required to implement a robust supervision model. The importance of supportive supervision was repeatedly emphasized; however, the investment in this area needed to be increased. Based on these challenges, as documented in the results, it is recommended that the time allocated for training should be increased. For example, a three-day training was suggested to allow more time to practice the referral and reporting forms. Supervisors need logistical support to provide on-spot mentoring for CHWs on the supervision forms. Providing adequate copies of the referral forms to health facilities are suggested to improve documentation and reporting of the referral process. The remuneration system of cash, certificates, and other rewards should be strengthened to avoid delays and encourage CHWs in their work.
The challenges documented in the study also highlight the financial constraints and barriers NTD programs face in implementing such an integrated model that requires skilled human resources and logistics for routine activities. Funding allocation will significantly impact the sustainability and scaling up of the optimal model. Implementing the optimal model largely depends on donor support; components of the optimal model, such as the incentive package, will only be able to sustain with financial backing. With the documented success of integrating active case finding and collaboration at all health system levels through this study, national budgets should prioritize funding for integrated approaches to the case management of NTDs. Low reliance on donor funding will enable the NTDs program to make independent decisions and lead in prioritizing critical interventions.
Investment in integration
This study has shown how integrated case detection of NTDs is pivotal to achieving the global target of leaving no one behind [18]. The second WHO NTDs roadmap 2021–2030 prioritizes integrated approaches to achieving new global targets [35]. The increase in cases detected and diagnosed early in the disease through the optimal model outlined in this study enables evidence-based advocacy with policymakers. Optimal models for case detection, referral, and confirmation of suspect NTD cases rely on integrated approaches to training, supervision, referral, and remuneration embedded within existing health systems infrastructure. Equity and inclusion are also critical, particularly the gender of health workers and the inclusion of affected persons. The global NTD target SDG 3:3 can only be achieved through optimal case detection, referral, and confirmation models. Together, these approaches improve access to health services, thus reducing morbidity associated with NTDs.
Supporting information
S2 File. Detailed optimal model for case detection, referral, and confirmation.
https://doi.org/10.1371/journal.pone.0283856.s002
(TIFF)
Acknowledgments
We want to extend our gratitude to the following people, with whose support this project was successful. Many thanks to the Ministry of Health Liberia, the data collection team of Mohammad Dunbar and Otis Kpadeh, and the field drivers for their commitment and endurance during the data collection process. Many thanks to the Ministry of Health NTD program monitoring and evaluation team and the UL-PIRE for the approval to conduct the research, and finally, our most tremendous gratitude to the national stakeholders, clinical staff, CHAs, CHVs, CDDs, patients, and communities for their time to participate in this study. Finally, we appreciate Paul Saunderson and Stefanie Weiland’s review of earlier manuscript drafts, which contributed immensely to the final draft.
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