Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice
Fig 1
Brain uptake of [14C]docosahexaenoic acid (DHA) in 2-, 8-, 12-, and 24-month-old mice.
Brain/perfusate ratio of [14C]DHA as NE-DHA in the whole brain (a), olfactory bulb (b), forebrain (c), cortex (d), hippocampus (e), thalamus and hypothalamus (f), and cerebellum (g) of 2- (2M), 8- (8M), 12- (12M), and 24-month-old (24M) mice following in situ transcardiac brain perfusion for 1 min at 2 mL/min. Data are shown as the mean ± standard error of the mean (n = 4–15). Each closed symbol represents an individual value. *P < 0.05, **P < 0.01, ***P < 0.001, significantly different from 2-month-old group.