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A nonparametric alternative to the Cochran-Armitage trend test in genetic case-control association studies: The Jonckheere-Terpstra trend test

Fig 1

Power comparison between the Jonckheere-Terpstra trend test (TJT) and the Cochran−Armitage trend test .

The black solid line denotes TJT and the red dashed line denotes . Along the x-axis, θ = π/4, arctan 2, and π/2 correspond to dominant (D), additive (A), and recessive (R) genetic models, respectively. The y-axis is the average empirical power at the 0.05 level based on 10,000 replicates each. The disease prevalence equals 0.1. MAF: minor allele frequency.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0280809.g001