Humoral immunogenicity of a Coronavirus Disease 2019 (COVID-19) DNA vaccine in rhesus macaques (Macaca mulatta) delivered using needle-free jet injection
Fig 3
Cross-neutralizing antibody titers against SARS-CoV-2 VOCs from day 63 sera.
The top panel reports the PRNT50 titers, and the bottom panel the PsVNA50 titers for each animal. Animal identification (ID) are shown on x-axis. Animals 1–6 were vaccinated using the Stratis intramuscular jet injection device and animals 7–12 were vaccinated with 0.4 mg using the Tropis intradermal jet injection device. For the PRNT, there are three bars for each animal representing the titers against the vaccine strain (WA1), the Gamma variant, or the Beta variant of concern (VOC). For the PsVNA, there are four bars for each animal representing the titers against the vaccine-based pseudovirion WA1, or pseudovirions for the Beta, Delta, and Gamma VOC. Assay lower limits are shown as gray shaded area.