In Vitro neurotoxicity and myotoxicity of Malaysian Naja sumatrana and Naja kaouthia venoms: Neutralization by monovalent and Neuro Polyvalent Antivenoms from Thailand
Fig 5
Effect of pre-incubation of antivenoms to indirectly stimulated twitches and contractile responses to exogenous agonists in tissue exposed to Malaysian N.sumatrana and N.kaouthia.
Panels (A) and (B) indicate change in twitch height for tissues that were pre-incubated with recommended titer of Cobra Antivenom (CAV), Neuro Polyvalent Antivenom (NPAV) and King Cobra Antivenom (KCAV) and exposed to N.sumatrana and N.kaouthia venoms (5 μg/ml), respectively. Panels (C) and (D) indicate contractile responses to exogenous agonists in tissues that were pre-incubated with antivenoms after exposure to N.sumatrana and N.kaouthia venoms (5 μg/ml), respectively. NS indicates N.sumatrana venom and NK indicates N.kaouthia venom. * p < 0.05, significantly different than the respective venom alone (n = 3, one-way ANOVA).