Multi-omics assessment of dilated cardiomyopathy using non-negative matrix factorization
Fig 5
Distribution of the correlation coefficients for latent factor analysis and analysis of node degree of the resulting network.
A) The figure represents the distribution of the correlation coefficients for the correlations analysis performed for selected gene and CpG features (for LF 3). This distribution is compared to a distribution obtained by random selection of gene and CpG features. It is also compared to the distribution obtained in the m-QTL analysis. B) The barplots represent the mean R for the latent factor analysis as compared to random background. C) Average node degree for gene and CpG features per latent factor is represented. D) The sorted node degree values for all gene and CpG features for latent factor 3 are shown. The orange line represents the 90th percentile cut-off used for further analysis of high node-degree genes.