Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption
Fig 5
ZOL inhibits osteoclast formation in DMM-induced OA rats.
Analysis of osteoclast formation in subchondral bone stained with (A, B and C) TRAP in coronal sections of tibia at various time-points. Scale bar, 100 μm. Quantitative analysis of (D) Oc.S/BS at various time-points (n = 6 per group/time point). **P < 0.01 and ***P < 0.001, compared with sham+PBS group; ##P < 0.01 and ###P < 0.001, compared with DMM+PBS group.