Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa
Fig 5
Interactions between AAC(3)-IIIa and gentamicin.
Alternative binding conformation is shown in teal, and the symmetry mate in gray. Panel A represents the binding of gentamicin in chain A, where only one molecule of aminoglycoside was modeled. Panel B represents binding of gentamicin in chain B, where two molecules were alternative, and main (semi-transparent green) binders were modeled in. Hydrogen bonds between alternative mode of gentamicin binding and AAC(3)-IIIa are displayed in black, whereas distances between N-3 of the central ring are shown in burgundy.